Vitamin D: There is a Caveat to the Push for Increased Vit D, Don't Forget Magnesium

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Magnesium is an essential cofactor required by 3751 enzyme systems that promote an astounding number of biochemical reactors in the body. It is involved in cell recovery, cell regulation, and cell rhythm. While enzymes run your body, a handful of minerals are needed to activate and run these enzymes. These minerals are the key to making enzymes do their job. When you are depleted in key minerals, there’s nothing to make these necessary enzymes work. For example, Adenosine triphosphate (ATP) needs to be holding Magnesium to make energy. Without Magnesium, your cells can’t control the amount of calcium and can get stuck making exhaust – why you feel “exhausted.” These enzymes need energy to run and without Magnesium, there is no energy. Magnesium is the mineral of motion and emotion that brings us to the role of magnesium and vitamin D metabolism. New research by prominent scientists is indicating that people who are magnesium deficient and are instructed to supplement with Vitamin D could be in danger.  


“People are taking Vitamin D supplements but don't realize how it gets metabolized. Without magnesium, Vitamin D is not really useful or safe," says study co-author Mohammed S. Razzaque, MBBS, Ph.D., a professor of pathology at Lake Erie College of Osteopathic Medicine.

Research is showing that supplementing Vitamin D without Magnesium can be dangerous. It has been thought that over time we have lost the enzyme required to convert cholesterol to vitamin D, but this new research is showing that we didn't lose the enzyme, we’ve lost the much-needed minerals in this delicate process -- our enzymes can no longer do their job. 

"Vitamin D can't be metabolized without sufficient magnesium levels, meaning Vitamin D remains stored and inactive for as many as 50 percent of Americans. In addition, Vitamin D supplements can increase a person's calcium and phosphate levels even while they remain Vitamin D deficient. People may suffer from vascular calcification if their magnesium levels aren't high enough to prevent the complication.” (American Osteopathic Association)

Razzaque explains that consumption of Vitamin D supplements can increase a person's calcium and phosphate levels, even if they remain Vitamin D deficient. If their magnesium levels aren’t high enough to combat it, people may suffer from vascular calcification.

Patients with optimum magnesium levels require less Vitamin D supplementation to achieve sufficient Vitamin D levels. Magnesium also reduces osteoporosis, helping to mitigate the risk of bone fracture that can be attributed to low levels of Vitamin D, Razzaque noted.

Deficiency in either of these nutrients is reported to be associated with various disorders, including skeletal deformities, cardiovascular diseases, and metabolic syndrome. (Science Daily)


New research finds that magnesium may hold the key to understanding how Vitamin D levels relate to health and disease.

Dr. Qi Dai, a professor of medicine at Vanderbilt University Medical Center and the lead study author, previously reported on the relationship between magnesium intake and vitamin D levels in over 12,000 individuals taking part in the National Health and Nutrition Examination Survey (NHANES) 2001–2006 study.

New evidence shifts the focus onto magnesium, implicating it in playing a central role in determining how much Vitamin D our bodies can make. Dr. Dai and his team found that individuals with high levels of magnesium intake, whether from dietary sources or supplementation, were less likely to have low levels of vitamin D. The researchers also found a possible association between magnesium intake and a decreased mortality rate particularly when they looked at mortality related to cardiovascular disease and bowel cancer.

So, how does magnesium affect Vitamin D in the body? It is a cofactor in the synthesis of vitamin D from both exposure to sunlight and dietary sources. "Magnesium deficiency shuts down the vitamin D synthesis and metabolism pathway," Dr. Dai explains.


In your body, 3,751 out of 9000 enzymes are dependent on magnesium. Iron eats magnesium for breakfast and forces it out of your cells. Pathogens, mold, bacteria, and parasites all feed on a buffet of unbounded, excess iron. The more you supplement Vitamin D and iron, the more inflammation your body will experience. You need to constantly stay on top of your magnesium. To learn more about iron and its role in the body read Iron Is The New Cholesterol by Clayton Dalton.

While topical magnesium creams, balms, gels and oils may not deliver the highest dose of magnesium, they can be an effective way to meet the necessary daily requirements without stomach upset and diarrhea. Our topical magnesium creams and balms are a great addition to your magnesium supplementation program and can help reduce anxiety, depression, tension, muscle cramping, restless leg syndrome, migraines, reduce pain, and elevate your magnesium status.